Protein name:
Midkine (MK) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer (By similarity). Interacts with ALK.
Function:
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.
Subcellular Location:
Secreted
Protein Attributes:
50:
MQHRSFFLLA | LVALLAVTTA | VAKKKDKVKK | GSECSEWTWG | PCTPSSKDCG |
100:
MGFREGTCGA | QTQRIHCKVP | CNWKKEFGAD | CKYKFESWGA | CDGSTGTKAR |
140:
QGTLKKARYN | AQCQETIRVT | KPCTSKTKSK | AKAKKGKGKD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Polyclonal Antibody for Rat MK
Polyclonal Antibody for Rat MK
Polyclonal Antibody for Rat MK
Monoclonal Antibody for Rat MK
Monoclonal Antibody for Rat MK
Monoclonal Antibody for Rat MK
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Neointima formation in a restenosis model is suppressed in midkine-deficient mice."
Horiba M.
,
Kadomatsu K.
,
Nakamura E.
,
Muramatsu H.
,
Ikematsu S.
,
Sakuma S.
,
Hayashi K.
,
Yuzawa Y.
,
Matsuo S.
,
Kuzuya M.
,
Kaname T.
,
Hirai M.
,
Saito H.
,
Muramatsu T.
J. Clin. Invest.105:489-495(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INDUCTION
strain :
Sprague-Dawley .
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DEVELOPMENTAL STAGE
strain :
Sprague-Dawley .
tissue :
Fetal adrenal gland .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE